Neurodegeneration
Combating toxic protein aggregation and neuroinflammation to preserve synaptic density and halt progressive neural decay.
Biological Focus & Mechanisms
Proteopathy Clearance
Targeting misfolded protein aggregates (tau, amyloid, alpha-synuclein) for lysosomal degradation.
Neuroinflammation
Modulating microglia activation states and reducing chronic neurotoxic cytokine release.
Synaptic Preservation
Supporting neurotrophic factor expression (BDNF/GDNF) to maintain dendritic spine density.
CNS Delivery Engineering
Optimizing engineered neurotropic capsids for non-invasive blood-brain barrier penetration.
Development Pipeline & Logic
CNS Model Validation
Screening target engagement in human induced pluripotent stem cell-derived neural models.
Vector Tropism
Engineering neurotropic capsids with high neuronal transduction and minimal off-target uptake.
Functional Recovery
Measuring synaptic electrophysiology, axonal transport, and cognitive preservation in vivo.
Clinical Endpoints
Incorporating fluid biomarkers (NfL, p-tau217) and quantitative neuroimaging registries.
Connect with our translational research team at contact@triplehelixscience.com