Longevity
Targeting conserved cellular aging drivers, epigenetic instability, and metabolic decline to extend human healthspan and delay age-associated physiological decay.
Biological Focus & Mechanisms
Cellular Senescence
Investigating senotherapeutic modalities to selectively clear dysfunctional senescent cells and reduce pro-inflammatory SASP burden.
NAD+ & Sirtuins
Modulating critical metabolic co-factors and mitochondrial sirtuin pathways to sustain bioenergetic capacity and DNA repair.
Epigenetic Reprogramming
Exploring transient, controlled transcription factor expression to restore youthful chromatin landscapes without dedifferentiation.
Mitochondrial Quality
Enhancing mitophagy kinetics and mitochondrial biogenesis to maintain cellular energy homeostasis and reduce oxidative stress.
Development Pipeline & Logic
Pathway Discovery
Profiling conserved longevity pathways in human cell models and aging biomarkers.
Target Engagement
Assessing metabolic biomarkers, epigenetic clock metrics, and target binding affinity.
Preclinical Models
Testing durability, systemic toxicity, and physiological resilience in vivo.
Clinical Framework
Designing ethics-governed clinical observational cohorts and safety registries.
Connect with our translational research team at contact@triplehelixscience.com